Throughout the centuries, the geographic region of Macedonia - which represents a natural crossroads - has been contested by various kingdoms and empires. Macedonia as the Pearl of the Balkans has diverse terrain which matches her rich history. Her national parks showcase the true beauty of the country.
The Republic of Macedonia produces wine on some 22,400 hectares (55,000 acres) of vineyards, and the production was 108,100 tons in 2008.  There are also some additional 30,000 hectares (74,000 acres) of vineyards dedicated to table grapes.
The production of red wine dominates the Macedonian wine production, with around 80 per cent.
In the European Union 'Macedonian wine' is a protected geographical indication (PGI) for wine from Macedonia/Greece.
In the culture of Ancient Macedonia, which covered a larger geographical area than today's Republic of Macedonia, wine played an important role.  While part of Yugoslavia, Macedonia was a major producer of wine. In the 1980s, it accounted for around two-thirds of the Yugoslav wine production. After the breakup of Yugoslavia, the Macedonian wine production decreased dramatically, from 1.8 million hectoliters in the mid-1990s to 447,000 hl in 2002.
Macedonia has three wine-growing regions:
- Povardarje, around the capital Skopje, centrally located in the country and the most important region.
- Pcinja-Osogovo, to the east on the border with Bulgaria.
- Pelagonija-Polog, around Lake Ohrid, to the west on the border with Albania.
The grape varieties common in cultivation includes a large proportion of indigenous varieties and varieties common to Central Europe and the Balkans, as well as some international varieties. Red varieties include Vranec (Vranac) (the most common variety of Macedonia), Kratošija, Cabernet Sauvignon and Merlot. White varieties include Smederevka, Welschriesling (usually referred to as Laški Rizling), Chardonnay, Sauvignon Blanc and Žilavka